Varicella-Zoster Virus (VZV)

Varicella-Zoster Virus (VCV), a member of the human herpesvirus family, causes chicken pox (varicella) and shingles (zoster). More than 90% of the population develops a varicella infection by the time they reach adolescence, and virtually 100% of the population will develop it until the age of 60. When VZV reactivates, it is known as zoster. During their lifetimes, 10-20% of all people will develop zoster.

VZV infections are medically significant, causing approximately 4 million cases of varicella and 500,000 cases of zoster each year.

In immunosuppressed patients the highly infectious Varicella-Zoster Virus causes significant morbidity.

The LightMix^® Kit VZV is based on the amplification of the Orf28 gene and provides a fast, easy and accurate system to identify and quantify this target in a nucleic acid extract. A control amplification reaction acts as internal control (IC). This kit has been tested on the LightCycler^® 1.x and 2.0 Instruments with Roche Diagnostics ‘LightCycler^® FastStart DNA Master HybProbe’.

References

Diagnosis of Variacella-Zoster Virus Infections in the Clinical Laboratory by LightCycler PCR. Espy, et al., Clin. Microbiology 38 (2000) 3187-3189

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